Leiomyosarcoma of Prostate
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Keywords

Prostate
Sarcoma
Leiomyosarcoma

How to Cite

1.
Heddat A, Houry Y, Rabii R. Leiomyosarcoma of Prostate: A Case Report and literature review. Health Sci. [Internet]. 2020Jun.17 [cited 2020Sep.27];2020. Available from: http://mbmj.org/index.php/hs/article/view/178

Abstract

Prostate leiomyosarcoma is an extremely rare and very aggressive neoplasm that represents less than 0.1% of primary malignant tumors of the prostate. We present a patient with primary leiomyosarcoma of  prostate and examine the cases reported in the literature to discuss the clinical, diagnostic and therapeutic aspects of this rare tumor. Median survival was estimated at 17 months (95% CI 20.7–43.7 months) and the actuarial survival rates at 1, 3 and 5 years were 68%, 34% and 26%, respectively. The only predictors of long-term survival were negative surgical margins and the absence of metastatic disease at presentation. A multidisciplinary approach is necessary for the proper management of this terrible entity.

Surgery with or without chemotherapy seems to be the main therapeutic method for operable leimyosarcomas, but in general there is no consensus on the best therapeutic approach. Most cases are diagnosed at an advanced stage of the disease. A global multicenter trial is needed to find therapies that would improve the prognosis.

https://doi.org/10.15342/hs.1.178
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Copyright (c) 2020 Abdeljalil Heddat et al.