Glycemic Control and Diabetes Macroangiopathy
PDF

Keywords

Diabetes
Glycemic Control
Macrovascular Complications
Trials

Categories

How to Cite

1.
Bordier L, Bauduceau B. Glycemic Control and Diabetes Macroangiopathy. Integr J Med Sci [Internet]. 2020 May 3 [cited 2024 Mar. 29];4:23-7. Available from: https://mbmj.org/index.php/ijms/article/view/52

Abstract

The issue of the efficacy of optimal glycemic control in the prevention of macroangiopathic complications of diabetes has been the subject of recent controversy. Although the facts are clear for microangiopathy, particularly in type 1 diabetes, they appear less certain for the cardiovascular complications of type 2 diabetes. This is due to the involvement of other cardiovascular risk factors that are very common in these patients. However, long-term follow-up studies are in favor of the interest of good glycemic control on macroangiopathic complications. The negative results on the mortality of the ACCORD study and the concerns regarding rosiglitazone led to the establishment of studies on the safety of new molecules. All this work led to the demonstration of the absence of risk of prescription of iDPP-4 and the very positive effect of certain molecules of the class of analogues of GLP-1 and iSGLT2.
It is to be hoped that the recent publication of the Academy of Medicine stressing that complications of type 2 diabetes require multifactorial prevention that necessarily involves an optimized control of the glycemic balance put an end of this unnecessary and dangerous polemic.

https://doi.org/10.15342/ijms.v4is.136
PDF

References

Cugnet-Anceau C, Bauduceau B. Equilibre glycémique et morbimortalité cardiovasculaire : apport des études 2008. Ann Endocrinol. 2009 Mar;70(1):1-8. https://doi.org/10.1016/j.ando.2008.12.009

Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia. 2015 Mar; 58:429-42. https://doi.org/10.1007/s00125-014-3460-0

HAS Recommandation de bonne pratique. Stratégie médicamenteuse du contrôle glycémique du diabète de type 2. [Accessed 21 Jun 2021]. Available From: https://www.has-sante.fr/upload/docs/application/pdf/2013-02/10irp04_reco_diabete_type_2.pdf

Jaffiol C, Godeau P. Les complications du diabète de type 2 exigent une prévention multifactorielle qui passe obligatoirement par un contrôle optimisé de l'équilibre glycémique. Communiqué de l'Académie nationale de Médecine du 6 octobre 2015.

Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008 Oct 9;359:1577-89. https://doi.org/10.1056/nejmoa0806470

Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005 Dec 22; 353:2643-53. https://doi.org/10.1056/nejmoa052187

Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8;360 (2):129-39. https://doi.org/10.1056/nejmoa0808431

Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M et al. ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12; 358:2560-72. https://doi.org/10.1056/nejmoa0802987

Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12; 358(24):2545-59. https://doi.org/10.1056/nejmoa0802743

Gerstein HC, Miller ME, Genuth S, Buse JB, Goff DC Jr, Probstfield JL, et al. Long-Term Effects of Intensive Glucose Lowering on Cardiovascular Outcomes. N Engl J Med. 2011 Mar 3; 364(9):818-28. https://doi.org/10.1056/nejmoa1006524

Ray KK, Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet. 2009 May 23; 373(9677):1765-72. https://doi.org/10.1016/s0140-6736(09)60697-8

Nissen SE, Wolski K. Rosiglitazone revisited: an updated metaanalysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med. 2010 Jul; 170(14):1191-1201. https://doi.org/10.1001/archinternmed.2010.207

Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, MassiBenedetti M, Moules IK, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspectivepioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet. 2005 Oct 8; 366:1279-89. https://doi.org/10.1016/s0140-6736(05)67528-9

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003 May 21 ;289(19):2560-72. https://doi.org/10.1001/jama.289.19.2560

Sinclair A, Morley JE, Rodriguez-Mañas L, Paolisso G, Bayer T, Zeyfang A, et al. Diabetes mellitus in older people: position statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes. J Am Med Dir Assoc. 2012 Jul;13(6):497-502. https://doi.org/10.1016/j.jamda.2012.04.012

White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, et al; EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013 Oct 3; 369(14):1327-35. https://doi.org/10.1056/nejmoa1305889

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, et al; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013 Oct; 369:1317-26. https://doi.org/10.1056/nejmoa1307684

Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, et al; TECOS Study Group. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015 Jul 16; 373(3):232-42. https://doi.org/10.1056/nejmoa1501352

Zinman B, Schmidt WE, Moses A, Lund N, Gough S. Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial program. Diabetes Obes Metab. 2012 Jan; 14(1):77-82. https://doi.org/10.1111/j.1463-1326.2011.01493.x

Wu JH, Foote C, Blomster J, Toyama T, Perkovic V, Sundström J, et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2016 May; 4(5):411-9. https://doi.org/10.1016/s2213-8587(16)00052-8

Ferrannini E, Mark M, Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care. 2016 Jul; 39(7):1108-14. https://doi.org/10.2337/dc16-0330

Zinman B, Schmidt WE, Moses A, Lund N, Gough S. Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial program. Diabetes Obes Metab. 2012 Jan; 14(1):77-82. https://doi.org/10.1111/j.1463-1326.2011.01493.x

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck AM, et al Trial Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2016 Jul 28; 375(4):311-22. https://doi.org/10.1056/nejmoa1603827

Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10; 375:1834-44. https://doi.org/10.1056/nejmoa1607141

Roussel R, Travert F, Pasquet B, Wilson PW, Smith SC Jr, Goto S, et al; Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch Intern Med. 2010 Nov 22; 170(21):1892-9. https://doi.org/10.1001/archinternmed.2010.409

Eriksson JW, Bodegard J, Nathanson D, Thuresson M, Nyström T, Norhammar A. Sulphonylurea compared to DPP-4 inhibitors in combination with metformin carries increased risk of severe hypoglycemia, cardiovascular events, and all-cause mortality. Diabetes Res ClinPract. 2016 Jul; 117:39-47. https://doi.org/10.1016/j.diabres.2016.04.055

Filion KB, Azoulay L, Platt RW, Dahl M, Dormuth CR, Clemens KK, et al. A Multicenter Observational Study of Incretin-based Drugs and Heart Failure. N Engl J Med. 2016 Mar 24; 374(12):1145-54. https://doi.org/10.1056/nejmoa1506115

Hsu PF, Sung SH, Cheng HM, Yeh JS, Liu WL, Chan WL, et al. Association of clinical symptomatic hypoglycemia with cardiovascular events and total mortality in type 2 diabetes: a nationwide population-based study. Diabetes Care. 2013 Apr; 36(4):894-900. https://doi.org/10.2337/dc12-0916

Gill GV, Woodward A, Casson IF, Weston PJ. Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisited. Diabetologia. 2009 Jan; 52(1):42-5. https://doi.org/10.1007/s00125-008-1177-7

Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008 Feb 7; 358(6):580-91. https://doi.org/10.1056/nejmoa0706245

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2017 Lyse Bordier Et al.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...