Relationship between Melanoma Stage at the Diagnosis and Survival During a Period of 30 Years (1982-2011)
PDF

Keywords

Melanoma
Stage
Diagnosis
Survival
Saudi Arabia

Categories

How to Cite

1.
Alkhaldi TM, Dawari SA, Aldaham SA. Relationship between Melanoma Stage at the Diagnosis and Survival During a Period of 30 Years (1982-2011). Integr J Med Sci [Internet]. 2018 Mar. 26 [cited 2024 Mar. 29];5. Available from: https://mbmj.org/index.php/ijms/article/view/91

Abstract

Melanoma is a malignant tumor of melanocytes and is a potentially aggressive cancer. The incidence of melanoma is rising at a greater rate than any other cancer in the U.S. The aim of this study was to examine the association between melanoma stage at the time of diagnosis and survival among U.S. adult melanoma patients during 1982-2011. This was a secondary analysis of a non-concurrent cohort study conducted on 185219 U.S. adult patients who were diagnosed with primary cutaneous melanoma between 1982-2011. Chi-square, Kaplan-Meier, and Cox proportional hazards regression were used to analyze the data. Significance was assessed using a p-value and 95% confidence interval. Men had more cutaneous melanoma. Black non-Hispanic patients were diagnosed less frequently. Patients who were married or in a domestic partnership were most likely to be diagnosed. The adjusted HR for distant melanoma was 141-fold that of in situ (95% CI 126.38-157.19). The adjusted HR was the highest in the first decade of diagnosis (1.7; 95% CI 1.6 1.75). In conclusion, survival is highly affected by the melanoma stage at diagnosis. Black non-Hispanic patients had the lowest hazard ratio of all races. The sample size was large, which enhances the generalizability to the U.S. population.

https://doi.org/10.15342/ijms.v5ir.190
PDF

References

Sladden MJ, Balch C, Barzilai DA, Berg D, Freiman A, Handiside T, et al.Surgical excision margins for primary cutaneous melanoma. John Wiley & Sons. 2009 Oct. https://doi.org/10.1002/14651858.CD004835.pub2

Chang AE, Karnell LH, Menck HR. The National Cancer Data Base Report on Cutaneous and Noncutaneous Melanoma. Cancer. 1998 Oct 15; 83(8):1664-78. https://doi.org/10.1002/(sici)10970142(19981015)83:8%3C1664::aid-cncr23%3E3.0.co;2-g

Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. Jan-Feb 2012; 62(1): 10-29. https://doi.org/10.3322/caac.20138

Jiang AJ, Rambhatla PV, Elide MJ. Socioeconomic and lifestyle factors and melanoma: a systematic review.Br J Dermatol. 2015 Apr; 172(4): 885-915. https://doi.org/10.1111/bjd.13500

Dickson PV, Gershenwald JE. Staging and Prognosis of Cutaneous Melanoma. Surg Oncol Clin N Am. 2011 Jan; 20:1-17. https://doi.org/10.1016/j.soc.2010.09.007

Buzaid AC, Ross MI, Balch CM, Soong S, McCarthy WH, Tinoco L, et al. Critical analysis of the current American Joint Committee on Cancer staging system for cutaneous melanoma and proposal of a new staging system. J Clin Oncol. 1997 Mar;15(3):1039-51. https://doi.org/10.1200/jco.1997.15.3.1039

Buttner P, Garbe C, Bertz J, Burg G, D’hoedt B, Drepper H, et al. Primary cutaneous melanoma. Optimized cutoff points of tumor thickness and importance of Clark's level for prognostic classification. Cancer. 1995 May15; 75:2499-2506. https://doi.org/10.1002/1097-0142(19950515)75:10%3C2499::aid-cncr2820751016%3E3.0.co;2-8

Edge S, Green F, Byrd DR, Compton CC, Brookland RK, Wachington MK, et al. AJCC Cancer Staging Manual. Springer Verlag; New York: 2009. [Accessed 30 June 2021]. Available From : https://www.springer.com/gp/book/9783319406176

Lemish WM, Heenan PJ, Holmand DJ, Armstrong BK, Phil D. Survival from Preinvasive and lnvasive Malignant Melanoma in Western Australia. Cancer. 1983 Aug; 52. https://doi.org/10.1002/10970142(19830801)52:3%3C580::AID-CNCR2820520334%3E3.0.CO;2-H

Menon IA, Persad S, Sanadive NS, Haberman HF. Effects of Ultraviolet-visible Irradiation in the Presence of Melanin Isolated from Human Black or Red Hair upon Ehrlich Ascites Carcinoma Cells. Cancer Res. 1983 Jul; 43(7): 3165-9.

Brenner M, Hearing VJ.The protective role of melanin against UV damage in human skin. Photochem Photobiol. May-Jun 2008; 84(3): 539-49. https://doi.org/10.1111/j.1751-1097.2007.00226.x

Karjalainen S, Hakulinen T. Survival and Prognostic Factors of Patients with Skin Melanoma. Cancer. 1988 ;62(1):2274-2280. [Accessed 30 June 2021]. Available From: https://acsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819881115%2962%3A10%3C2274%3A%3AAIDCNCR2820621034%3E3.0.CO%3B2-J

Vries ED, Nijsten TEC, Visser O, Bastiaannet E, Hatten SV, Janssen-Heijnen ML, et al. Superior survival of females among 10,538 Dutch melanoma patients is independent of Breslow thickness, histologic type and tumor site. Ann Oncol. 2008 Mar; 19(3): 583-9. https://doi.org/10.1093/annonc/mdm498

Ortiz CAR, Freeman JL, Kuo YF, Goodwin JS. The Influence of Marital Status on Stage at Diagnosis and Survival of Older Persons with Melanoma. J Gerontol. 2007 Aug; 68(8):892-898. https://doi.org/10.1093/gerona/62.8.892

Zell JA, Cinar P, Mobasher M, Zioagas A, Meyskens FL, Anton-Culver H. Survival for patients with invasive cutaneous melanoma among ethnic groups: the effects of socioeconomic status and treatment. J Clin Oncol. 2008 Jan 1: 26(1): 66-75. https://doi.org/10.1200/jco.2007.12.3604

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2018 Talal M Alkhaldi et al.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...