Introduction: Myxomas are rare benign tumors of soft tissue, represent 1% of adult cancers, they are most often located in the intramuscular compartment, particularly in the thigh. They are most often observed in elderly patients between the fifth and seventh decade, particularly females.
Case report: We present the case of a 60-year-old man with a painless and several years progressive mass of the medial aspect of the left thigh. Magnetic Resonance Imaging (MRI) has shown a tissue mass with a cystic lesion. In addition, histopathological diagnosis of the specimen was in favor of an intramuscular myxoma without signs of malignancy. Short and long-term follow-up of two years did not detect any recurrence.
Conclusion: The slowly growing character is not an argument of benignity, in contrast to other situations. Therefore, the myxoid component may be present in other soft tissue malignant tumors, specially liposarcoma. This difficulty sometimes imposing more specimen verification or a second opinion. Although myxomas are rare, it is important to keep them in mind when a myxoid component is present and distinguish them from sarcomas.
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