Keywords
Hyposmia
COVID-19
MRI
Olfactory tract
Imaging
Categories
How to Cite
Abstract
Anosmia is a prevalent and pathognomonic symptom in patients with Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), often accompanied by changes of taste or dysgeusia. It is also one of the symptoms that lasts the most even after the recovery. The studies that examine the migration path and timing of SARS-CoV-2 are needed in order to determinate the ideal timing for realizing an MRI so as to possibly find an abnormal signal on the olfactory bulb.
References
Gorbalenya A. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020 Apr;5(4):536-544. https://doi.org/10.1038/s41564-020-0695-z
Letko MC, Munster V. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. bioRxiv. 2020. https://dx.doi.org/10.1101%2F2020.01.22.915660
WHO. WHO Coronavirus Disease (COVID-19) Dashboard, 2020. [Accessed 2020 Mar 29]. Available from: https://covid19.who.int
Ministry of Health of Morocco, 2020. Rabat, Morocco. [Accessed 2020 Mar 29]. Available from: https://www.sante.gov.ma/
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579: 270–3. https://doi.org/10.1038/s41586-020-2012-7
Wu C, Zheng M. Single-cell RNA expression profiling shows that ACE2, the putative receptor of COVID-2019, has significant expression in nasal and mouth tissue, and is co-expressed with TMPRSS2 and not co-expressed with SLC6A19 in the tissues. Preprint. 2020. [Accessed 2020 Mar 29]. Available from: https://www.researchsquare.com/article/rs-16992/v1
Wu C, Zheng M. Single-cell RNA expression profiling shows that ACE2, the putative receptor of COVID-2019, has significant expression in nasal and mouth tissue, and is co-expressed with TMPRSS2 and not co-expressed with SLC6A19 in the tissues. Preprint. 2020. [Accessed 2020 Mar 29]. Available from: https://www.researchsquare.com/article/rs-16992/v1
Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020 Feb 24;12(1):8. https://doi.org/10.1038/s41368-020-0074-x
Brann DH, Tsukahara T, Weinreb C, Logan DW, Datta SR. Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients. BioRxiv. 2020. https://doi.org/10.1101/2020.03.25.009084
Hopkins C, Kumar N. Loss of sense of smell as marker of COVID-19 infection. ENT UK. 2020.
Rabin R. Lost sense of smell may be peculiar clue to coronavirus infection The New York Times. 2020. [Accessed 2020 Mar 29]. Available from: https://www.nytimes.com/2020/03/22/health/coronavirus-symptoms-smell-taste.html
Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, et al. COVID-19 and the chemical senses: supporting players take center stage. Neuron. 2020 Jul 22;107(2):219-233. https://doi.org/10.1016/j.neuron.2020.06.032
Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. https://doi.org/10.1007/s00405-020-05965-1
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, Chusakul S, Seresirikachorn K, Snidvongs K. Olfactory and gustatory dysfunctions in COVID-19 patients: a systematic review and metaanalysis. Asian Pac J Allergy Immunol. 2020 Sep;38(3):162-169. https://doi.org/10.12932/ap-210520-0853
Politi LS, Salsano E, Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia. JAMA Neurol. 2020; 77(8):1028-1029. https://doi.org/10.1001/jamaneurol.2020.2125
Strauss SB, Lantos JE, Heier LA, Shatzkes DR, Phillips CD. Olfactory Bulb Signal Abnormality in Patients with COVID-19 Who Present with Neurologic Symptoms. AJNR Am J Neuroradiol. 2020 Oct;41(10):1882-1887. https://doi.org/10.3174/ajnr.a6751
Kandemirli SG, Altundag A, Yildirim D, Tekcan Sanli DE, Saatci O. Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia. Acad Radiol. 2021 Jan;28(1):28-35. https://doi.org/10.1016/j.acra.2020.10.006
Galougahi MK, Ghorbani J, Bakhshayeshkaram M, Naeini AS, Haseli S. Olfactory Bulb Magnetic Resonance Imaging in SARS-CoV-2-Induced Anosmia: The First Report. Acad Radiol. 2020 Jun;27(6):892-893. https://doi.org/10.1016/j.acra.2020.04.002
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