Multiple Myeloma Revealed by a Sphenoid Plasmocytoma: Case Report and Literature Review
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Keywords

Multiple myeloma
Plasmocytoma
Sphenoid
Skull base

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How to Cite

1.
Kadiri S. Multiple Myeloma Revealed by a Sphenoid Plasmocytoma: Case Report and Literature Review. Integr J Med Sci [Internet]. 2016 Jan. 30 [cited 2024 Jul. 24];3:57-9. Available from: https://mbmj.org/index.php/ijms/article/view/44

Abstract

Plasma cell neoplasms can manifest as solitary or multiple plasmacytomas and may be associated with or progressing to multiple myeloma (MM). Cranial and intracranial plasmacytomas revealing multiple myeloma are very rare and only a few cases are reported in the literature.
We report the case of a sphenoid plasmacytoma that revealed multiple myeloma in a 56-year-old woman with 3 months history of temporal headache and diplopia. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a sphenoid mass. An endoscopic sphenoidal biopsy was performed and the histopathological exams showed a plasmacytoma with positive staining for CD138. Further biological studies confirmed the diagnosis of multiple myeloma with a monoclonal gamma peak of immunoglobulin (Ig) A. The patient started systemic chemotherapy and received decompressive radiation therapy on the sphenoidal sinus. She remained in remission for 8 months and died from renal dysfunction. 
Although the sphenoid plasmacytoma is a very rare presentation of multiple myeloma it should be considered for effective patient management and prognosis improvement.

https://doi.org/10.15342/ijms.v3i2.103
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References

Cerase A, Tarantino A, Gozzetti A, Muccio CF, Gennari P, Monti L, et al. Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay. Neuroradiology. 2008 Aug, 50(8):665–74. https://doi.org/10.1007/s00234-008-0390-x

Terada T. Multiple myeloma presenting as an intracranial plasmacytoma: a case report. Cases J. 2009 Nov 30; 2:9110. https://doi.org/10.1186/1757-1626-2-9110

Sin WY, Grant I. Intracranial plasmacytoma with hypoglossal nerve palsy in multiple myeloma. Postgrad Med J. 2015 Mar; 91:174-5. https://doi.org/10.1136/postgradmedj-2014-133051

Kyle RA, Rajkumar SV. Epidemiology of the plasma-cell disorders. Best Pract Resh Clin Haematol. 2007 Dec;20(4):637-64. https://doi.org/10.1016/j.beha.2007.08.001

Yaman E, Benekli M, Coskun U, Sezer K, Ozturk B ,Kaya OA, et al. Intrasellar plasmacytoma: an unusual presentation of multiple myeloma. Acta Neurochir. 2008 Sep, 150(9):921-4. https://doi.org/10.1007/s00701-008-0012-8

Bladé J, Rosiñol L .Complications of multiple myeloma. Hematol Oncol Clin North Am. 2007 Dec, 21(6):1231-46. https://doi.org/10.1016/j.hoc.2007.08.006

Wavre A, Baur AS, Betz M, Mühlematter D, Jotterand M, Zaman K, Ketterer N. Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma. Neuro Oncol. 2007 Jul; 9(3):370-2. https://doi.org/10.1215/15228517-2007-008

Ustuner Z, Basaran M, Kiris T, Bilgic B, Sencer S, Sakar B, et al. Skull base plasmacytoma in a patient with light chain myeloma. Skull Base. 2003 Aug; 13:167–71. https://doi.org/10.1055/s-2003-43327

Higurashi M, Yagishita S, Fujitsu K, Kitsuta Y, Takemoto Y, Osano S. Plasma cell myeloma of the skull base: report of two cases. Brain Tumor Pathol. 2004;21(3):135-41.https://doi.org/10.1007/bf02482189

Peker S, Abacioglu U, Bayrakli F, Kilic T, Pamir MN. Gamma knife radiosurgery for cavernous sinus plasmacytoma in a patient with breast cancer history. Surg Neurol, 2005 Feb ; 63(2):174-6. https://doi.org/10.1016/j.surneu.2003.12.013

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2016 Selma Kadiri

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