Nephrotic Syndrome Revealing of a Squamous Cell Bronchial Carcinoma


Paraneoplastic nephrotic syndrome
Squamous Bronchial Carcinoma
Extramembranous Glomerulonephritis

How to Cite

Sbiki L, lefqih imane, Taoufiq R, sabur S, elaamadi wafae, achir abdellah, Bouchikh M. Nephrotic Syndrome Revealing of a Squamous Cell Bronchial Carcinoma. ATD [Internet]. 2022 Jul. 14 [cited 2024 Apr. 17];2022. Available from:


Malignant broncho-pulmonary tumors are the principal cause of the paraneoplastic nephrotic syndrome. These tumors are most often small cell or squamous bronchial carcinomas. In 75% of cases, the nephrotic syndrome is due to membranous glomerulonephritis. We report the case of a 67 years old patient, a chronic tobacco user, followed since June 2019 for a nephrotic syndrome caused by extra-membranous glomerulonephritis. A chest computed tomography revealed a mass of the left lower lobe.  Trans-parietal biopsy of this process revealed a squamous bronchial carcinoma. PET scan detected no other fixations. The proteinemia was at 39g/l with albuminemia at 14 g/l. Surgical resection was then indicated and the patient underwent a left lower lobectomy with radical lymph adenectomy. Outcomes were simple with complete resolution of paraneoplastic nephrotic syndrome.


F. Menivale1, G. Deslée1, V. Garcia1, H. Sartelet2, A. Wynckel3, F. Lebargy1 Syndrome néphrotique paranéoplasique et cancers broncho-pulmonaires 3 observations et revue de la littérature Rev Mal Respir 2005 ; 22 : 325-9.

Eagen JW, Lewis EJ : Glomerulopathies of neoplasia. Kidney Int 1977 ; 11 : 297-306.

Usalan C, Emri S : Membranoproliferative glomerulonephritis associated with small cell lung carcinoma. Int Urol Nephrol 1998 ; 30 :209-13.

JC, Yamauchi H, Hopper J Jr : The association of cancer and the nephrotic syndrome. Ann Intern Med 1966 ; 64 : 41-51.

Boon ES, Vrij AA, Nieuwhof C, van Noord JA, Zeppenfeldt E : Small cell lung cancer with paraneoplastic nephrotic syndrome. Eur Respir J 1994 ; 7 : 1192-3.

Helin H, Pasternack A, Hakala T, Penttinen K, Wager O : Glomerular electron-dense deposits and circulating immune complexes in patients with malignant tumours. Clin Nephrol 1980 ;14 : 23-30.

Ashman N, Steele JP, Sheaff M, Rudd RM, Onwubalili J : Membranous nephropathy resolving with treatment of bronchial carcinoid tumor. Am J Kidney Dis 2000 ; 36 : 15.

Norris SH : Paraneoplstic glomerulopathies. Semin Nephrol 1993 ; 13 : 258-72.

Lefaucher C, Stengel B, Nochy D, Martel P, Hill GS, Jacquot C, et al. Membranous nephropathy and cancer: epidemiologic evidence and determinants of high risk cancer association. Kidney Int 2006;70:1510-7.

I. Yangui1 , S. Msaad1 , M. Smaoui1 , S. Makni3 , K. Kammoun2 , A. Khébir3 , T. Boudawara3 , A. Ayoub Cas clinique Carcinome à petites cellules du poumon et syndrome néphrotique d’évolution rapidement fatale Rev Pneumol Clin 2007 ; 63 : 331-334.

Paydas S, Soydas B, Paydas S, Balal M, Erdogan S, Tuncer I. Different glomerulopathies accompanying non-small-cell lung cancer. Mt Sinai J Med 2005;72:279-81.

Ebert B, Shaffer K, Rennke H. Some unusual paraneoplastic syndromes. Case 4- Paraneoplastic nephrotic syndrome in a patient with lung cancer. J Clin Oncol 2003;21:26245.

Coltharp WH, Lee SM, Miller RF, Averbuch MS. Nephrotic syndrome complicating adenocarcinoma of the lung with resolution after resection. Ann Thorac Surg 1991;5:308-9.

Grivaux M, Renault D, Gallois JC, Barbanel C, Blanchon F. Carcinome à petites cellules révélé par une glomérulonéphrite extramembraneuse. Rev Mal Respir 2001;18:19.

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Copyright (c) 2022 Sbiki L et al.


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