Keywords
ENT
Sarcomas
Cancers
Surgery
Categories
How to Cite
Abstract
Introduction: Head and neck sarcomas are rare, malignant, and very heterogeneous tumors. The difficulty to manage these sarcomas requires the intervention of a multidisciplinary team to improve the prognosis. The aim of our study is to report our series (epidemiological, histological, and progressive characteristics) and evaluate our treatment results.
Patients and methods: This is a retrospective study on 42 cases of head and neck sarcomas, assembled at ENT and Maxillofacial Surgery department in the University Hospital of Rabat, for a period of 5 years (2010-2015). All sarcomas were confirmed by histological examination with immunohistochemical study.
Results: There were 29 men and 13 women. The average age of our patients was 35.5 years (extremes of age: 13 and 70 years). All patients received a CT scan with MRI scan in 21 cases. A remote extension assessment showed lung metastases in 8 cases. The most frequently found histological type was synovial sarcoma, which was noted in 13 patients (30.9%) followed by osteosarcoma (21.2%). The osteosarcoma treatment was curative in 19 cases, based on surgery with radiotherapy. Total remission was noted in twelve patients.
Conclusion: Head and neck sarcomas are rare and very aggressive cancers with a poor prognosis. The treatment approach combines surgery and chemoradiation. However, in the absence of adequate and effective treatment protocols, it is necessary to establish a surgical indication in time to ensure excision as complete as possible.
References
Potter O, Sturgis M. Sarcomas of the head and neck region. Curr Opin Oncol. 2003 May; 15(3):239-52. https://doi.org/10.1097/00001622-200305000-00011
Hoffman T, Robinson A, Spiess L, Buatti J. Update in management of head and neck sarcoma. Curr Opin Oncol. 2004 Jul; 16(4): 333-41. https://doi.org/10.1097/01.cco.0000127880.69877.75
Shellenberger T, Sturgis EM. Sarcomas of the head and neck region. Curr Oncol Rep. 2009 Mar; 11(2):135–42. https://doi.org/10.1007/s11912-009-0020-8
Ketabchi A, Kalavrezos N, Newman L. Sarcomas of the head and neck: a 10year retrospective of 25 patients to evaluate treatment modalities, function and survival. Br J Oral Maxillofac Surg. 2011 Mar; 49(2):116–20. https://doi.org/10.1016/j.bjoms.2010.02.012
Kraus HD, Dubner S, Harrison BL, Strong WE, Hajdu IS, Kher U, et Al. Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas. Cancer. 1994 Jul 15; 74(2):697–702. https://doi.org/10.1002/1097-0142(19940715)74:2%3C697::aid-cncr2820740224%3E3.0.co;2-a
Lyos T, Goepfert H, Luna A, Jaffe N, Malpica A. Soft tissue sarcoma of the head and neck in children and adolescents. Cancer.1996 Jan 1; 77(1):193–200. https://doi.org/10.1002/(sici)1097-0142(19960101)77:1%3C193::aid-cncr31%3E3.0.co;2-z
Pandey M, Thomas G, Mathew A, Abraham A, Somanathan T, Ramadas K, et al. Sarcoma of the oral and maxillofacial soft tissue in adults. Eur J Surg Oncol. 2000 Mar; 26(2):145–8. https://doi.org/10.1053/ejso.1999.0758
Penel N, Mallet Y, Robin YM, Fournier C, Grosjean J, Ceugnart L, et al. Prognostic factors for adult sarcomas of head and neck. Int J Oral Maxillofac Surg. 2008 May; 37(5):428–32. https://doi.org/10.1016/j.ijom.2008.01.019
Penel N, Haverbeke CV, Lartigau E, Vilain MO, Van JT, Mallet Y, et al. Head and neck soft tissue sarcomas of adult: prognostic value of surgery in multimodal therapeutic approach. Oral Oncol. 2004 Oct; 40(9):890–7. https://doi.org/10.1016/j.oraloncology.2004.04.001
Rapidis AD, Gakiopoulou H, Stavrianos SD, Vilos GA, Faratzis G, Douzinas EE, et al. Sarcomas of the head and neck. Results from the treatment of 25 patients. Eur J Surg Oncol. 2005 Mar; 31(2):177–82. https://doi.org/10.1016/j.ejso.2004.09.020
De Bree R, Van der Valk P, Kuik DJ, Van Diest J, Doornaert P, Buter J, et al. Prognostic factors in adult soft tissue sarcomas of the head and neck: a singlecentre experience. Oral Oncol. 2006 Aug; 42 (7):703–9. https://doi.org/10.1016/j.oraloncology.2005.11.009
Hoekstra HJ, Thijssens K, Van Ginkel RJ. Role of surgery as primary treatment and as intervention in the multidisciplinary treatment of soft tissue sarcoma. Ann Oncol. 2004; 15 Suppl 4:iv181–6. https://doi.org/10.1093/annonc/mdh924
Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG. Sarcomas of the head and neck. Prognostic factors and treatment strategies. Cancer. 1992 Jul 1; 70 (1):169–77. https://doi.org/10.1002/1097-0142(19920701)70:1%3C169::aid-cncr2820700127%3E3.0.co;2-f
Coindre JM. Biologie moléculaire des sarcomes. Bulletin du Cancer. 2010 Nov; 97(11): 1337-45. https://doi.org/10.1684/bdc.2010.1213
Ballo MT, Zagars GK, Cormier JN, Hunt KK, Feig BW, et al. Interval between surgery and radiotherapy: effect on local control of soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2004 Apr 1; 58(5):1461–7. https://doi.org/10.1016/j.ijrobp.2003.09.079
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Copyright (c) 2015 Rajae Borki et al.
