Keywords
Antituberculosis therapy
SHIV-negative
Categories
How to Cite
Abstract
Background: Paradoxical reactions during anti-TB treatment represent a real challenge to pneumo-phthisiologists and require a high index of suspicion. It has been suggested that this reaction during appropriate treatment is common and severe in HIV-negative individuals. Our objective was to determine the frequency of paradoxical reactions and their associated features. Method: A prospective study was undertaken in a population of HIV-TB+ patients to determine the frequency of paradoxical reactions and their associated features. Results: Paradoxical reactions occurred in 1.5% of all our hospital’s TB patients. Conclusion: Paradoxical reactions during anti-TB treatment is common in HIV-uninfected individuals and must be considered after careful exclusion of medication non-adherence, other infections, development of resistance, and other similar conditions.
References
Hawkey CR, Yap T, Pereira J, Moore DA, Davidson RN, Pasvol G, et al. Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis. Clin Infect Dis. 2005 May 1; 40(9):1368-71. https://doi.org/10.1086/429317
Breton G. Syndrome inflammatoire de reconstitution immune (IRIS) associé à la tuberculose. J Anti-infectieux. 2012 Nov;14(4):180-5. https://doi.org/10.1016/j.antinf.2012.09.001
Cheng VC, Ho LP, Lee RA, Chan SK, Chan KK, Woo P, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur J Clin Microbiol Infect Dis. 2002 Nov; 21(11):803-9. https://doi.org/10.1007/s10096-002-0821-2
Al-Majed S. Study of paradoxical response to chemotherapy in tuberculous pleural effusion. Respiratory medicine. 1996 Apr; 90(4):211-4. https://doi.org/10.1016/s0954-6111(96)90289-9
Campbell I, Dyson AJ. Lymph node tuberculosis: a comparison of various methods of treatment. Tubercle. 1977 Dec; 58(4):171-9. https://doi.org/10.1016/0041-3879(77)90041-1
Memish Z, Mah M, Mahmood SA, Bannatyne R, Khan M. Clinico diagnostic experience with tuberculous lymphadenitis in Saudi Arabia. Clin Microbiol Infect. 2000 Mar; 6(3):137-41. https://doi.org/10.1046/j.1469-0691.2000.00033.x
Choremis CB, Padiatellis C, Zou Mbou Lakis D, Yannakos D. Transitory exacerbation of fever and roentgenographic findings during treatment of tuberculosis in children. Am Rev Tuberc. 1955 Oct; 72(4):527. https://doi.org/10.1164/artpd.1955.72.4.527
Orlovic D, Smego J. Paradoxical tuberculous reactions in HIVinfected patients. Int J Tuberc Lung Dis. 2001 Apr; 5(4):370-5. [Accessed 31th May 2021]. Available From: https://www.ingentaconnect.com/content/iuatld/ijtld/2001/00000005/00000004/art00013
Park I-S, Son D, Lee C, Park EJ, Lee J-S, Cheong M-H, et al. Severe paradoxical reaction requiring tracheostomy in a human immunodeficiency virus (HIV)-negative patient with cervical lymph node tuberculosis. Yonsei Med J. 2008 Oct 31; 49(5):853-6. https://doi.org/10.3349/ymj.2008.49.5.853
Martinez V, Bricaire F. Réactions paradoxales. Presse Med. 2006 Nov;35(11):1747-1750. https://doi.org/10.1016/s0755-4982(06)74893-x
Narita M, Ashkin D, Hollender ES, Pitchenik AE. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Am J Respir Crit Care Med. 1998 Jul; 158(1):157-61. https://doi.org/10.1164/ajrccm.158.1.9712001
Vidal CG, Garau J. Systemic steroid treatment of paradoxical upgrading reaction in patients with lymph node tuberculosis. Clin Infect Dis. 2005 Sep 15; 41(6):915-6. https://doi.org/10.1086/432807
Rakotoarivelo R, Vandenhende M-A, Michaux C, Morlat P, Bonnet F. Réactions paradoxales sous traitement antituberculeux chez des personnes non infectées par le VIH: quatre nouvelles observations et revue de la littérature. Rev Med Interne. 2013 Apr; 34(4):202-8. https://doi.org/10.1016/j.revmed.2012.08.014
Cheng VC, Yam WC, Woo PC, Lau SK, Hung IF, Wong SP, et al. Risk factors for development of paradoxical response during antituberculosis therapy in HIV-negative patients. Eur J Clin Microbiol Infect Dis. 2003 Oct; 22(10):597-602. https://doi.org/10.1007/s10096-003-0998-z
Rao GP, Nadh BR, Hemaratnan A, Srinivas TV, Reddy PK. Paradoxical progression of tuberculous lesions during chemotherapy of central nervous system tuberculosis: report of four cases. J Neurosurg. 1995 Aug; 83(2):359-62. https://doi.org/10.3171/jns.1995.83.2.0359
Fontanilla J-M, Barnes A, Von Reyn CF. Current diagnosis and management of peripheral tuberculous lymphadenitis. Clin Infect Dis. 2011 Sep; 53(6):555-62. https://doi.org/10.1093/cid/cir454
Guinchard A-C, Pasche P. Lymphadénite tuberculeuse cervicale et réaction paradoxale: diagnostic et traitement. ORL. 2012 Oct; 356(34):1860-5. [Accessed 31th May 2021]. Available From : https://www.revmed.ch/revue-medicale-suisse/2012/revue-medicale-suisse-356/lymphadenite-tuberculeuse-cervicale-et-reaction-paradoxale-diagnostic-et-traitement
Colebunders R, John L, Huyst V, Kambugu A, Scano F, Lynen L. Syndrome inflammatoire de reconstitution immunitaire de la tuberculose dans les pays à ressources limitées. Int J Tuberc Lung Dis. 2006;10(9):946-53.
Malone JL, Paparello S, Rickman LS, Wagner KF, Monahan B, Oldfield EC. Intracranial tuberculoma developing during therapy for tuberculous meningitis. West J Med. 1990 Feb; 152(2):188-190. [Accessed 10th June 2021]. Available From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002313/
Valdez LM, Schwab P, Okhuysen PC, Rakita RM. Paradoxical subcutaneous tuberculous abscess. Clin Infect Dis. 1997 Apr; 24(4):734. https://doi.org/10.1093/clind/24.4.734
Bouchez B, Arnott G, Colover J. Paradoxical expansion of intracranial tuberculomas during chemotherapy. Lancet. 1984 Aug 25; 324(8400):470-1. https://doi.org/10.1016/S0140-6736(84)92950-7
Société de Pneumologie de Langue Française. [Recommendations of the French Language Pneumology Society for tuberculosis management in France: consensus conference – brief text]. Rev Mal Respir. 2004 Jun; 21(3 Pt 2):S5-11.
Rabar D, Issartel B, Petiot P, Boibieux A, Chidiac C, Peyramond D. Tuberculomes et méningoradiculite tuberculeuse d’évolution paradoxale sous traitement. Presse Med. 2005 Jan 15 ; 34(1):32-4. https://doi.org/10.1016/s0755-4982(05)83881-3
Chambers ST, Record C, Hendrickse WA, Rudge P, Smith H. Paradoxical expansion of intracranial tuberculomas during chemotherapy. Lancet. 1984 Jul 28; 2 (8396):181-4. https://doi.org/10.1016/s0140-6736(84)90478-1
Safdar A, Brown AE, Kraus DH, Malkin M. Paradoxical reaction syndrome complicating aural infection due to Mycobacterium tuberculosis during therapy. Clin Infect Dis. 2000 Mar; 30(3):625-7. https://doi.org/10.1086/313731
Hejazi N, Hassler W. Multiple intracranial tuberculomas with atypical response to tuberculostatic chemotherapy: literature review and a case report. Infection. Jul-Aug 1997; 25(4):233-9. https://doi.org/10.1007/bf01713151
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Copyright (c) 2015 Sanae Hammi et al.
